Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA2256 | CA34784 | U.S. | 2002 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 29 |
| 2 | AZT+DDC | 78 |
| 3 | 3TC+AZT+SQV | 8 |
| 4 | AZT | 17 |
| 5 | 3TC+AZT+RTV | 9 |
| 6 | 3TC+AZT | 51 |
| 7 | D4T+IDV | 16 |
| 8 | D4T+IDV+RTV | 54 |
| 9 | D4T+DDI+RTV+SQV | 33 |
| 10 | D4T+DDI+EFV+RTV+SQV | 13 |
| 11 | Unknown | 131 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, L74V, L210W, T215Y | L100I, K103N | V35I, K43N, R83K, K122E, I135M, I178IL, G196E, T200A, I202IV, Q207E, R211K, E224ED, L228R, V245E, A272P, K277R, Q278H, T286A, E297R, E312X |
| >CA34784| codons 1-315 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALIEICTELENEGKISKIGPENPYNTPV FAIKKKDSTKWRKVVDFRELNKKTQDFWEVQLGIPHPAGIKKNKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSMNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDLVI YQYMDDLYVGSDLEIEQHRAKVEELREHLWKWGFYTPDKKHQKDPPFRWMGYELHPDKWT VQPIELPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRHLCKLLRGAKALTEVIPLTREAE LELAENREILKXPVH |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, I54V, V82IT, L90LM | L10I, I15V, K20R, M36I, N37D, L63P, A71V, I85IV |
| >CA33769| codons 1-99 PQITLWQRPIVTIKVGGQLREALLDTGADDTILEEIDLPGRWKPKMIGGIGGFVKVRQYD QIPIEICGHKVIGTVLVGPTPINIVGRNLMTQIGCTLNF |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |