<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
GFLPB046 GFLPB046 South Africa 2014 HIV1 C Plasma None

Treatment History
Order Regimen Weeks
1 3TC+EFV+TDF 94

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
K65R, L74I, Y115F, M184V   V106M V179D, F227L V8I, V35T, E36A, T39E, S48T, V60I, S68N, K122E, D123G, K173T, D177E, T200A, I202V, Q207E, V245Q, D250E, A272P, E291D, V292I, I293V, K311R, G335D, M357R, G359A, T377M, K390R, E399D, A400I, E404D, V435E  
>GFLPB046| codons 1-436
PISPIETIPVKLKPGMDGPKVKQWPLTEEKIKALTAICEEMEKEGKITKIGPENPYNTPI
FAIKRKDNTKWRKIVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSMTVLDVGDAFFSVPL
DEGFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRTQNPEIDI
YQYVDDLYVGSDLEIGQHRAKVEELREHLLRWGFTTPDKKHQKEPPLLWMGYELHPDKWT
VQPIQLPEKESWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTDIVPLTEEAE
LELAENREILREPVHGVYYDPSKDLIAEIQKQGQDQWTYQIYQEPFKNLKTGKYARRRAA
HTNDVKQLTEAVQKIAMESIVIWGKTPKFRLPIQKETWDIWWTDYWQATWIPEWEFVNTP
PLVKLWYQLEKEPIEG

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
    T12S, K14R, I15V, Q18E, L19T, K20R, E35D, M36I, R41K, L63T, H69K, T74S, L89M, I93L  
>GFLPB046| codons 1-99
PQITLWQRPLVSIRVGGETREALLDTGADDTVLEDINLPGKWKPKMIGGIGGFIKVRQYD
QITIEICGKKAIGSVLVGPTPVNIIGRNMLTQLGCTLNF

References
Author Title Citation
Steegen, K HIV-1 antiretroviral drug resistance patterns in patients failing NNRTI-based treatment: results from a national survey in South Africa. J Antimicrob Chemother, 2016