Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA6583 | CA34659 | U.S. | 2002 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 52 |
| 2 | 3TC+AZT | 9 |
| 3 | 3TC+AZT+SQV | 22 |
| 4 | 3TC+AZT+IDV | 104 |
| 5 | AZT+RTV+SQV | 30 |
| 6 | 3TC+ABC+EFV | 65 |
| 7 | APV+D4T+RTV | 35 |
| 8 | 3TC+AZT+LPV+NVP | 48 |
| 9 | APV+EFV+IDV+TDF | 17 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74I, M184MV, L210W, T215Y | K219N | K103N, Y181C | V108VI | K43N, A98S, V118VI, D177N, G196E, Q207H, H208HY, R211K, H221Y, A272S, T286A, E297K |
| >CA34659| codons 1-301 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELENEGKISKIGPENPYNTPV FAIKKKNSTKWRKIVDFRELNKRTQDFWEVQLGIPHPSGLKKNKSVTILDVGDAYFSIPL DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPNIVI CQYVDDLYVGSDLEIEQHRTKIEELRHYLWKWGFYTPDNKYQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYSGIKVKQLCKLLRGAKALTEVIPLTKEAE L |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54IL, L90M | G73A | L10I, K20KM, R41KT, L63P, A71T, I72R, V77I, I93L |
| >CA33639| codons 1-99 PQITLWQRPIVTIKIGGQLMEALLDTGADDTVLEEMNLPGKWKPKIIGGIGGFLKVRQYD QIPIEICGHKTRATVLIGPTPVNIIGRNLMTQLGCTLNF |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |