Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA1128 | CA34653 | U.S. | 2002 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 47 |
| 2 | DDI+ AZT | 49 |
| 3 | DDC+ AZT | 5 |
| 4 | RTV+ DDI+ AZT | 22 |
| 5 | RTV+ AZT+ 3TC | 10 |
| 6 | IDV+ AZT+ 3TC | 15 |
| 7 | IDV+ D4T+ 3TC | 23 |
| 8 | SQV+ IDV+ D4T+ 3TC | 67 |
| 9 | ADV+ 3TC+ D4T+ NFV+ SQV | 127 |
| 10 | SQV+ NFV+ D4T+ 3TC | 101 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, M184V, L210W, T215Y | K219Q | E6D, T39A, E44D, K122E, I142V, I202V, R211K, T286A, A288T |
| >CA34653| codons 1-302 PISPIDTVPVKLKPGMDGPKVKQWPLTEEKIKALVEICAELEKDGKISKIGPENPYNTPV FAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYVDDLYVGSDLEIGQHRTKVEELRQHLWKWGFYTPDQKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGAKTLTEVIPLTEEAE LE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54V, V82A, I84V | L24I | L10I, K20X, E35ED, M36MI, D60DE, L63P, I64V, A71V | V75VM |
| >CA33637| codons 1-99 PQITLWQRPIVTIKIGGQLXEALIDTGADDTVLEDINLPGRWKPKLIGGIGGFVKVRQYE QIPVEICGHKVIGTMLVGPTPANVIGRNLLTQIGCTLNF |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |