<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
CA4517 CA34604 U.S. 2002 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 AZT 113
2 AZT+DDC 52
3 3TC+AZT 54
4 3TC+D4T+NVP+RTV 49
5 3TC+D4T+NVP+RTV+SQV 65
6 D4T+NVP+RTV+SQV 159

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, V75M, L210LW F77L, T215C, K219HN K101E, G190A   V35I, K43E, E44A, K82KR, R83K, V118I, K122P, S162ST, K173KE, I178IL, G196E, Q207E, A272P, K275R, K277R, K281KR, T286A, E297KR  
>CA34604| codons 1-301
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALIEICTELEEAGKISKIGPENPYNTPV
FAIKKKNSTKWRKLMDLRELNRKTQDFWEVQLGIPHPAGLEKKKSVTVLDVGDAYFSIPL
DPDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQTSMTKILEPFREQNPDLVI
YQYMDDLYVASDLEIEQHRTKIEELREHLWRWGFCTPDHKHQKEPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIRVRQLCRLLRGAKALTEVIPLTKEAE
L

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, G48V, V82A, I84V, L90M   L10I, F53FY, I62IV, L63HP, I64IV, A71V, V77I, I93L  
>CA33595| codons 1-99
PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEEMNLPGRWKPKIIVGIGGYIKVRQYD
QVHVEICGHKVIGTVLIGPTPANVIGRNLMTQLGCTLNF

References
Author Title Citation
Rhee, SY HIV-1 protease and reverse transcriptase mutations: Correlations with antiretroviral therapy in subtype B isolates and implications for drug-resistance surveillance. J Infect Dis, 2005