Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA5212 | CA34557 | U.S. | 2002 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 239 |
| 2 | 3TC+AZT | 109 |
| 3 | 3TC+AZT+IDV | 22 |
| 4 | 3TC+D4T+IDV | 35 |
| 5 | 3TC+D4T+NFV | 106 |
| 6 | 3TC+APV+D4T+NVP | 20 |
| 7 | 3TC+APV+D4T+NVP+RTV | 108 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, T69D, K70R, M184V | K219Q | Y181C, G190GA | V108I | K20R, T39TA, V60I, V118VI, D121DH, K122X, D123E, I135IT, I142IL, K166R, D177DE, V179I, F214L, H221Y, L228H, A272P |
| >CA34557| codons 1-285 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICAEMEKEGKISKIGPENPYNTPI FAIKKKNSDRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTILDVGDAYFSIPL HXEFRKYTAFTIPSTNNETPGLRYQYNVLPQGWKGSPAIFQSSMTRILEPFRKQNPEIII CQYVDDLYVASDLEIGQHRTKIEELRQHLLRWGLTTPDQKYQKEPPFHWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRG |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I84IV, L90M | L10F, Q58QE | I13V, K20I, E34EK, I54X, K55KR, D60E, Q61E, I62V, L63P, I93L |
| >CA33544| codons 1-99 PQITLWQRPFVTVKIGGQLIEALLDTGADDTVLKEMNLPGRWKPKIIGGIGGFXRVREYE EVPIEICGHKAIGTVLVGPTPVNVIGRNLMTQLGCTLNF |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |