<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
CA5271 CA34532 U.S. 2002 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 AZT+DDI 187
2 None 4
3 3TC+AZT 4
4 3TC+AZT+RTV 30
5 3TC+AZT+IDV 113
6 None 12
7 3TC+AZT+IDV 30
8 None 8
9 3TC+AZT+EFV 48
10 None 8
11 3TC+ABC+AZT 63

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41ML, D67~, K70R, L74V, M184V, T215F T69G, K219Q     A98S, K101X, I135V, D192E, T200TA, R211K, D218DE, L228H, V245T, K277R, L283I, I293V E29EG
>CA34532| codons 1-300
PISPIETVPVKLKPGMDGPKVKQWPLTEGKIKALVEICTELEKEGKISKIGPENPYNTPV
FAIKKK~SGRWRKVVDFRELNKRTQDFWEVQLGIPHPSGLXKKKSVTVLDVGDAYFSVPL
DKDFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI
YQYVDDLYVGSELEIGQHRAKIEELRQHLLKWGFFTPEQKHQKEPPFHWMGYELHPDKWT
VQPITLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVRQLCKLIRGTKALTEVVPLTEEAE

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
    L63P  
>CA33518| codons 1-99
PQITLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMNLPGRWKPKMIGGIGGFIKVRQYD
QIPIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF

References
Author Title Citation
Rhee, SY HIV-1 protease and reverse transcriptase mutations: Correlations with antiretroviral therapy in subtype B isolates and implications for drug-resistance surveillance. J Infect Dis, 2005
Rhee, SY Predictive value of HIV-1 genotypic resistance test interpretation algorithms. J Infect Dis, 2009