<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
CA14297 CA34491 U.S. 2002 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 AZT 48
2 3TC+AZT 22
3 3TC+AZT+IDV 52
4 3TC+DDC+NFV 31
5 D4T+DDI+DLV 78
6 ABC+APV+D4T+DDI 140

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, L210W, T215Y       K20R, K32E, V35VL, T39AE, E40F, K43KE, R83K, V90I, V118I, K122E, T139K, K173T, I178L, G196E, Q207E, H208Y, V245E, E297A  
>CA34491| codons 1-300
PISPIETVPVKLKPGMDGPRVKQWPLTEEKIEALLEICAFLEEEGKISKIGPENPYNTPV
FAIKKKNSTKWRKLVDFRELNKKTQDFWEIQLGIPHPAGLKKKKSVTVLDVGDAYFSIPL
DEDFRKYTAFTIPSINNEKPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRTQNPDLVI
YQYMDDLYVGSDLEIEQHRTKIEELREYLWRWGFYTPDKKHQKEPPFLWMGYELHPDKWT
VQPIELPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGTKALTEVIPLTAEAE

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
I54L K43T L10I, I15V, E34K, E35D, M36I, I62T, L63P, A71V, I93L K20E
>CA33484| codons 1-99
PQITLWQRPIVTIKVGGQLEEALLDTGADDTVLKDINLPGRWTPKMIGGIGGFLKVRQYD
QTPIEICGHKVIGTVLVGPTPVNIIGRNLLTQLGCTLNF

References
Author Title Citation
Rhee, SY HIV-1 protease and reverse transcriptase mutations: Correlations with antiretroviral therapy in subtype B isolates and implications for drug-resistance surveillance. J Infect Dis, 2005