Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA4516 | CA34488 | U.S. | 2002 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | 3TC+AZT | 5 |
| 2 | 3TC+AZT+SQV | 6 |
| 3 | 3TC+AZT+IDV | 9 |
| 4 | 3TC+D4T+IDV | 101 |
| 5 | NVP+DDI+NFV | 7 |
| 6 | DLV+DDI+NFV | 29 |
| 7 | EFV+DDI+NFV | 32 |
| 8 | ABC+D4T+Unknown+APV+NFV | NA |
| 9 | Unknown | 90 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M184V | K103KN | A98S, D123E, I142V, I178L, V179I, I195IL, G196E, T200A, R211K, A272S, T286A, V292I, E297K |
| >CA34488| codons 1-301 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPSGLKKNKSVTVLDVGDAYFSVPL DKEFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDLII YQYVDDLYVGSDLELEQHRAKIEELRQHLLKWGFTTPDKKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYSGIKVKQLCKLLRGAKALTEIIPLTKEAE L |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, V82A | L24I, K43T | K55KR, D60N, L63P, A71V, I93L |
| >CA33480| codons 16-99 GGQLKEALIDTGADDTVLEEMNLPGRWTPKIIGGIGGFVRVRQYNQIPIEICGHKVIGTV LVGPTPANIIGRNLLTQLGCTLNF |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |