Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA4061 | CA34375 | U.S. | 2002 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 52 |
| 2 | DDC | 52 |
| 3 | 3TC+AZT+SQV | 30 |
| 4 | 3TC+AZT+IDV | 43 |
| 5 | DDI+NFV+NVP | 26 |
| 6 | 3TC | 74 |
| 7 | 3TC+EFV+IDV+RTV | 143 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M184V, L210W | T215C | K101E, Y181C, G190A | K20R, K49R, I50V, T69TS, R83K, D121Y, K122E, I135V, R211K, P243T, V245K, D250E, A272P, I293V, E297R |
| >CA34375| codons 1-300 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICTEMEKEGKISRVGPENPYNTPV FAIKKKDSSKWRKLVDFRELNKKTQDFWEVQLGIPHPAGLEKKKSVTVLDVGDAYFSVPL YEDFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI CQYVDDLYVASDLEIGQHRTKIEELRQHLWKWGFCTPDKKHQKEPPFLWMGYELHPDKWT VQTIKLPEKESWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTEVVPLTREAE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I84V, L90M | G73S | L10I, I13IV, E35D, M36I, R57K, D60E, Q61E, I62V, L63P, A71V, I72R, I85IV |
| >CA33360| codons 1-99 PQITLWQRPIVTVKIGGQLKEALLDTGADDTVLEDINLPGRWKPKMIGGIGGFIKVKQYE EVPIEICGHKVRSTVLVGPTPVNVVGRNLMTQIGCTLNF |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |