Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA5391 | CA34303 | U.S. | 2002 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 178 |
| 2 | D4T+IDV | 52 |
| 3 | DDI+NFV | 30 |
| 4 | 3TC+NFV+AZT | 60 |
| 5 | D4T+NFV+3TC | 43 |
| 6 | 3TC+AZT+LPV | 43 |
| 7 | ABC+EFV+3TC | 12 |
| 8 | 3TC+D4T+NFV | 43 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, L74V, M184V, L210W, T215Y | D67G, K219N | Y181C | K43KQ, S68G, R83K, V118I, K166R, E169K, K173E, Q207E, R211K, D218E, A272P, K277R, T286A |
| >CA34303| codons 1-292 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEQEGKISKIGPENPYNTPV FAIKKKGGTKWRKVVDFRELNKKTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSIPL DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTRILKPFREQNPDIVI CQYVDDLYVGSDLEIGQHRTKIEELREHLWKWGFYTPENKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGAKALTEV |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, V82F, L90M | I13IV, I15V, K20M, E35D, M36V, R41K, I62V, L63P, T74S, I93L |
| >CA33286| codons 1-99 PQITLWQRPLVTVKVGGQLMEALLDTGADDTVLEDVNLPGKWKPKIIGGIGGFIKVRQYD QVPIEICGHKAIGSVLVGPTPFNIIGRNLMTQLGCTLNF |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |