Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA4378 | CA34244 | U.S. | 2002 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT+DDI | 44 |
| 2 | 3TC+AZT | 26 |
| 3 | 3TC+AZT+IDV | 48 |
| 4 | 3TC+D4T+NFV | 31 |
| 5 | NVP+RTV+SQV | 72 |
| 6 | 3TC+ABC+APV+AZT+RTV | 33 |
| 7 | 3TC+ABC+AZT+IDV+RTV | 103 |
| 8 | 3TC+DLV+LPV+SQV | 52 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, M46I, I47V, I54V, V82A, L90M | L10F, K43T, F53L, G73S | I13V, I15V, G16A, N37D, K55R, L63P, A71V |
| >CA34244| codons 1-99 PQITLWQRPFVTVKVAGQLKEALLDTGADDTILEEMDLPGRWTPKIVGGIGGLVRVRQYD QIPIEICGHKVISTVLVGPTPANIIGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67DN, M184V, T215TFIS | K219Q | V179D | K20R, V118I, K122E, I135T, G196E, F214L, L228LH, A272P, E297A |
| >CA35259| codons 1-300 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSIPL DEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIDI YQYVDDLYVGSDLEIEQHRTKIEELRQHLLRWGLSTPDQKHQKEPPFHWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTEVIPLTAEAE |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |