<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
CA2306 CA34240 U.S. 2002 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 DDI 70
2 D4T 35
3 3TC+D4T 74
4 3TC+AZT+DDC+IDV 48
5 ADV+DLV+RTV+SQV 54
6 3TC+ABC+AZT+EFV 29
7 ABC+D4T+DDI 44
8 3TC+APV+LPV 23
9 None 42
10 3TC+ABC+DDI+LPV 55

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I54V, V82A, I84V Q58E L10I, K20KR, M36MI, N37S, R41K, K55KR, L63P  
>CA34240| codons 1-99
PQITLWQRPIVTIKIGGQLREALLDTGADDTVLEEISLPGKWKPKIIGGIGGFVRVREYD
QIPIEICGHKAIGTVLVGPTPANVIGRNLLTQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
L74V, M184V       V35R, K122E, I135T, S162C, A272S, P294T W229W*
>CA35242| codons 1-300
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALREICTEMEKEGKISKIGPENPYNTPV
FAIKKKDSTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
DEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFRKQNPDIVI
YQYVDDLYVGSDLEIGQHRTKIEELRQHLLRWGFTTPDKKHQKEPPFL*MGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYSGIKVKQLCKLLRGTKALTEVITLTEEAE

References
Author Title Citation
Rhee, SY HIV-1 protease and reverse transcriptase mutations: Correlations with antiretroviral therapy in subtype B isolates and implications for drug-resistance surveillance. J Infect Dis, 2005