Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA8000 | CA34197 | U.S. | 2002 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | D4T+3TC+IDV | 52 |
| 2 | 3TC+D4T+NFV | 13 |
| 3 | 3TC+D4T+NVP | 243 |
| 4 | None | 13 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| L10I, K20R, N37D, D60E, L63X, I64V, V77I, I85V, I93L |
| >CA34197| codons 1-99 PQITLWQRPIVTIKIGGQLREALLDTGADDTVLEEMDLPGRWKPKMIGGIGGFIKVRQYE QIXVEICGHKAIGTVLIGPTPVNIVGRNLLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M184V | A62V | Y181C | K238KT | K32KQ, D123E, I135R, K166KR, D177E, G196GE, T200TA, R211RG, F214L, H221HY, L228LR, V245E, E248Q, A272P, T286A, I293V, K366R, T369A, A376T, V381I, K390R, A400T, T403A, E404D, V435A, A437V, D460N, R461K, H483Y, L491S, S519N, W535R, A554N, I556V, K558R, V559I |
| >CA35213| codons 1-560 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIQALVEICTEMEKEGKISKIGPENPYNTPV FVIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DKEFRKYTAFTIPSRNNETPGIRYQYNVLPQGWKGSPAIFQSSMTRILEPFRKQNPEIVI CQYVDDLYVGSDLEIEQHRAKIEELRQHLLGWGLTTPDKKYQKEPPFRWMGYELHPDTWT VQPIELPQKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGAKALTEVVPLTEEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARMRGA HTNDVRQLAEAVQKITTESIIIWGKTPKFRLPIQKETWETWWADYWQATWIPEWEFVNTP PLVKLWYQLEKEPIAGVETFYVDGAANRETKLGKAGYVTNKGRQKVVSLTDTTNQKTELQ AIYLALQDSGSEVNIVTDSQYALGIIQAQPDKSESELVNQIIEQLIKKEKVYLARVPAHK GIGGNEQVDKLVSNGVRRIL |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |