Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA4873 | CA34186 | U.S. | 2002 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 230 |
| 2 | DDI | NA |
| 3 | Unknown | NA |
| 4 | 3TC+ AZT+ IDV | 170 |
| 5 | RTV+ 3TC+ AZT+ IDV | 34 |
| 6 | D4T+ DDI+ LPV | 128 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54V, V82A, L90M | V11I, L33F, G73S | L10IV, T12N, L19I, M36L, N37D, K55R, I62V, L63P, C67F, A71V, I72L |
| >CA34186| codons 1-99 PQITLWQRPIINIKIGGQIKEALLDTGADDTVFEELDLPGRWKPKLIGGIGGFVRVRQYD QVPIEIFGHKVLSTVLVGPTPANIIGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, T69D, K70R, T215F | K219Q | K101E | P1L, E28EA, E53EG, V60VI, A98S, D123E, I135T, S162Y, V179VI, I195T, T200A, V245K, A272P, A288S, I293IV |
| >CA35194| codons 1-301 LISPIETVPVKLKPGMDGPKVKQWPLTAEKIKALVEICTEMEKEGKISKIGPGNPYNTPI FAIKKKNSDRWRKLVDFRELNKRTQDFWEVQLGIPHPSGLEKKKSVTVLDVGDAYFSVPL DKEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQYSMTKILEPFRKQNPDIII YQYMDDLYVGSDLETGQHRAKIEELRQHLLRWGFFTPDQKHQKEPPFLWMGYELHPDKWT VQPIKLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKSLTEVVPLTEEAE L |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |