Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA4864 | CA34154 | U.S. | 2002 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 74 |
| 2 | AZT+DDC | 35 |
| 3 | 3TC+AZT+IDV | 187 |
| 4 | ABC+APV+D4T+NVP | 165 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54L, L90M | L33F, G73T, L89V | L10I, L63P, K70T |
| >CA34154| codons 1-99 PQITLWQRPIVTIKIGGQLKEALLDTGADDTVFEEMNLPGRWKPKMIGGIGGFLKVRQYD QIPIEICGHTAITTVLVGPTPVNIIGRNVMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74LI, L210W, T215Y | K219R | V106A | F227L | K43KE, V90VI, V118VI, K122E, D123E, I142V, S163SC, T165TI, I178L, V179I, G196E, K277R, T286A, A288T, E297K, R356K, A360T, T386I, K390R, A400T, V435L, N447NS, E449D, H483Y, L491S, Q520H, K527Q | L484IM |
| >CA35168| codons 1-560 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEEEGKISKIGPENPYNTPV FAIKKKNSTKWRKIVDFRELNKRTQDFWEIQLGIPHPAGLKKKKSATVLDVGDAYFSIPL DEEFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQSCMIKILEPFRKQNPDLII YQYMDDLYVGSDLEIEQHRTKIEELRQHLWRWGFYTPDRKHQKEPPLLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVRQLCKLLRGAKTLTEVIPLTKEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYAKMRGT HTNDVKQLTEAVQKIATESIVIWGKIPKFRLPIQKETWETWWTEYWQATWIPEWEFVNTP PLVKLWYQLEKEPILGAETFYVDGAASRDTKLGKAGYVTDRGRQKVVSLTDTTNQKTELQ AIYMALQDSGSEVNIVTDSQYALGIIQAQPDKSESELVSHIIEQLIQKEKVYLAWVPAHK GIGGNEQVDKLVSAGIRKVL |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |
| Rhee, SY | Predictive Value of HIV-1 Genotypic Resistance Test Interpretation Algorithms. | J Infect Dis, 2009 |