Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA1293 | CA34114 | U.S. | 2002 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT+DDI | 52 |
| 2 | 3TC+D4T | 52 |
| 3 | 3TC+D4T+IDV | 52 |
| 4 | 3TC+D4T+NFV+NVP | 189 |
| 5 | 3TC+D4T+NFV | 36 |
| 6 | 3TC+AZT+NFV | 79 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, V82A | L10F, L24I, L89V | G16GR, M36L, N37D, Q61E, I62V, L63P, I64M, A71V, I72T, I93L |
| >CA34114| codons 1-99 PQITLWQRPFVTIKIRGQLKEALIDTGADDTVLEELDLPGRWKPKLIGGIGGFIKVRQYD EVPMEICGHKVTGTVLVGPTPANIIGRNVLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, L74V, M184V, L210W, T215Y | Y181CG | V108I, V179EQ | V35I, K43Q, E44ED, A98S, K102Q, K103KR, V118I, D121C, K122E, D123DE, I135T, I142V, T200A, H208HY, K223Q, L228R, Q242L, V245M, A272P, K275R, K277R, P294T |
| >CA35131| codons 1-300 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALIEICTELEQDGKISKIGPENPYNTPV FAIKKKDSTKWRKVVDFRELNKRTQDFWEVQLGIPHPSGLKQRKSVTILDVGDAYFSIPL CEEFRKYTAFTIPSTNNETPGVRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIEI CQYVDDLYVGSDLEIGQHRAKIEELRQYLWRWGFYTPDKKHQQEPPFRWMGYELHPDKWT VLPIMLPEKDSWTVNDIQKLVGKLNWASQIYPGIRVRQLCKLLRGTKALTEVITLTEEAE |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |
| Rhee, SY | Predictive Value of HIV-1 Genotypic Resistance Test Interpretation Algorithms. | J Infect Dis, 2009 |