<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
CA1293 CA34114 U.S. 2002 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 AZT+DDI 52
2 3TC+D4T 52
3 3TC+D4T+IDV 52
4 3TC+D4T+NFV+NVP 189
5 3TC+D4T+NFV 36
6 3TC+AZT+NFV 79

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46L, V82A L10F, L24I, L89V G16GR, M36L, N37D, Q61E, I62V, L63P, I64M, A71V, I72T, I93L  
>CA34114| codons 1-99
PQITLWQRPFVTIKIRGQLKEALIDTGADDTVLEELDLPGRWKPKLIGGIGGFIKVRQYD
EVPMEICGHKVTGTVLVGPTPANIIGRNVLTQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, L74V, M184V, L210W, T215Y   Y181CG V108I, V179EQ V35I, K43Q, E44ED, A98S, K102Q, K103KR, V118I, D121C, K122E, D123DE, I135T, I142V, T200A, H208HY, K223Q, L228R, Q242L, V245M, A272P, K275R, K277R, P294T  
>CA35131| codons 1-300
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALIEICTELEQDGKISKIGPENPYNTPV
FAIKKKDSTKWRKVVDFRELNKRTQDFWEVQLGIPHPSGLKQRKSVTILDVGDAYFSIPL
CEEFRKYTAFTIPSTNNETPGVRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIEI
CQYVDDLYVGSDLEIGQHRAKIEELRQYLWRWGFYTPDKKHQQEPPFRWMGYELHPDKWT
VLPIMLPEKDSWTVNDIQKLVGKLNWASQIYPGIRVRQLCKLLRGTKALTEVITLTEEAE

References
Author Title Citation
Rhee, SY HIV-1 protease and reverse transcriptase mutations: Correlations with antiretroviral therapy in subtype B isolates and implications for drug-resistance surveillance. J Infect Dis, 2005
Rhee, SY Predictive value of HIV-1 genotypic resistance test interpretation algorithms. J Infect Dis, 2009