Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA6802 | CA34090 | U.S. | 2002 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT+DDC | 104 |
| 2 | 3TC+DDC+SQV | 13 |
| 3 | 3TC+DDC+IDV | 21 |
| 4 | NVP | 43 |
| 5 | 3TC+AZT+NVP+SQV | 56 |
| 6 | AZT+3TC+NVP+SQV | 17 |
| 7 | ABC+DDI+EFV+IDV | 17 |
| 8 | None | 39 |
| 9 | D4T+NVP+RTV+SQV | 47 |
| 10 | 3TC+ABC+LPV+NVP | 61 |
| 11 | 3TC+ABC+APV+AZT+TDF | 36 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| G48V, I50V, I54A, V82A | L10I, L19T, E34EQ, I62V, L63P, A71V, V77I, L90X, I93L |
| >CA34090| codons 1-99 PQITLWQRPIVTIKIGGQTKEALLDTGADDTVLQEMNLPGRWKPKMIVGVGGFAKVRQYD QVPIEICGHKVIGTVLIGPTPANIIGRNLXTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, L210W, T215Y | K219R | K101KE, V106A, Y181YC, G190GA | V108I, F227FL | K20R, V35I, K43E, E44A, V90VI, V118I, K122E, I135T, T165I, D177E, I178M, G196E, E203ED, Q207E, R211K, H221HY, A272P, K277R, T286A |
| >CA35102| codons 1-301 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALIEICTELEEAGKISKIGPENPYNTPV FAIKKKNSDKWRKLVDFRELNKRTQDFWEIQLGIPHPAGLEKKKSATILDVGDAYFSIPL DEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMIKILEPFRKQNPEMVI CQYMDDLYVASDLEIEQHRTKIDELREHLWKWGFYTPDRKYQKEPPLLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGAKALTEVIPLTEEAE L |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |