Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA1435 | CA34078 | U.S. | 2002 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 20 |
| 2 | AZT+D4T | 29 |
| 3 | 3TC+D4T | 12 |
| 4 | 3TC+AZT+D4T+IDV | 28 |
| 5 | DDC+RTV+SQV | 29 |
| 6 | AZT+DDI+NFV | 28 |
| 7 | ABC+EFV+RTV+SQV | 22 |
| 8 | 3TC+ABC+EFV+NFV | 26 |
| 9 | ABC+EFV+NFV | 15 |
| 10 | ABC+APV+EFV+NFV | 11 |
| 11 | ABC+APV+EFV+NFV | 4 |
| 12 | ABC+APV+NFV | 35 |
| 13 | 3TC+DDI+SQV | 48 |
| 14 | 3TC+DDI+LPV+SQV | 48 |
| 15 | 3TC+DDI+LPV+SQV+TDF | 26 |
| 16 | 3TC+DDI+LPV+TDF | 18 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, M46I, I54V, V82A, L90M | L10F, V11VI, L33F, K43PT, G73S | T12S, I15V, L19Q, M36L, N37S, K55R, I62V, L63P, A71V |
| >CA34078| codons 1-99 PQITLWQRPFISIKVGGQQKEALLDTGADDTIFEELSLPGRWPPKIIGGIGGFVRVRQYD QVPIEICGHKVISTVLVGPTPANIIGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67HN, T69D, K70R, L74IV, M184V, T215F | K219Q | V35K, T39A, V60I, K104KN, V118I, K122E, I135T, S162D, F214L, A272P, E297K |
| >CA35098| codons 1-301 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALKEICAELEKEGKISKIGPENPYNTPI FAIKKKHSDRWRKIVDFRELNKRTQDFWEVQLGIPHPAGLKKKNSVTVLDVGDAYFSIPL DEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQDSMTKILEPFRKQNPDIVI YQYVDDLYVGSDLEIGQHRTKIEELRQHLLRWGLFTPDQKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTEVIPLTKEAE L |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |
| Rhee, SY | Predictive Value of HIV-1 Genotypic Resistance Test Interpretation Algorithms. | J Infect Dis, 2009 |