Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA5532 | CA34022 | U.S. | 2002 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 122 |
| 2 | AZT+DDC | 52 |
| 3 | D4T+DDI | 22 |
| 4 | Unknown | 83 |
| 5 | 3TC+AZT+NFV | 246 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| D30N | N88D | L10I, I13V, I15V, M36V, N37S, P39PS, K45R, R57K, L63P, I64V, A71V, I93L |
| >CA34022| codons 1-99 PQITLWQRPIVTVKVGGQLKEALLDTGADNTVLEEVSLSGRWKPRMIGGIGGFIKVKQYD QIPVEICGHKVIGTVLVGPTPVNIIGRDLLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, M184V, L210W, T215Y | K43Q, V118I, K122KE, I142V, K166R, E204Q, Q207DE, R211K, A272P, K277R, I293V, E297A, S322T, I326V, A360V, K390R, E399D, K431N, R461K, S468T, L503I, Q509K, E529D |
| >CA35053| codons 1-560 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEQEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSIPL DEDFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQSSMTRILEPFRKQNPDIVI YQYVDDLYVGSDLEIGQHRTKIEQLRDHLWKWGFYTPDKKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTEVVPLTAEAE LELAENREILKEPVHGVYYDPTKDLVAEIQKQGQGQWTYQIYQEPFKNLKTGKYARMRGV HTNDVKQLTEAVQKIATESIVIWGKTPKFRLPIQKETWDAWWTEYWQATWIPEWEFVNTP PLVKLWYQLENEPIVGAETFYVDGAANRETKLGKAGYVTDKGRQKVVTLTDTTNQKTELQ AIHLALQDSGLEVNIVTDSQYAIGIIQAKPDKSESELVSQIIEQLIKKDKVYLAWVPAHK GIGGNEQVDKLVSAGIRKVL |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 protease and reverse transcriptase mutations: Correlations with antiretroviral therapy in subtype B isolates and implications for drug-resistance surveillance. | J Infect Dis, 2005 |