<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
CA5532 CA34022 U.S. 2002 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 AZT 122
2 AZT+DDC 52
3 D4T+DDI 22
4 Unknown 83
5 3TC+AZT+NFV 246

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
D30N N88D L10I, I13V, I15V, M36V, N37S, P39PS, K45R, R57K, L63P, I64V, A71V, I93L  
>CA34022| codons 1-99
PQITLWQRPIVTVKVGGQLKEALLDTGADNTVLEEVSLSGRWKPRMIGGIGGFIKVKQYD
QIPVEICGHKVIGTVLVGPTPVNIIGRDLLTQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, M184V, L210W, T215Y       K43Q, V118I, K122KE, I142V, K166R, E204Q, Q207DE, R211K, A272P, K277R, I293V, E297A, S322T, I326V, A360V, K390R, E399D, K431N, R461K, S468T, L503I, Q509K, E529D  
>CA35053| codons 1-560
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEQEGKISKIGPENPYNTPV
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSIPL
DEDFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQSSMTRILEPFRKQNPDIVI
YQYVDDLYVGSDLEIGQHRTKIEQLRDHLWKWGFYTPDKKHQKEPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTEVVPLTAEAE
LELAENREILKEPVHGVYYDPTKDLVAEIQKQGQGQWTYQIYQEPFKNLKTGKYARMRGV
HTNDVKQLTEAVQKIATESIVIWGKTPKFRLPIQKETWDAWWTEYWQATWIPEWEFVNTP
PLVKLWYQLENEPIVGAETFYVDGAANRETKLGKAGYVTDKGRQKVVTLTDTTNQKTELQ
AIHLALQDSGLEVNIVTDSQYAIGIIQAKPDKSESELVSQIIEQLIKKDKVYLAWVPAHK
GIGGNEQVDKLVSAGIRKVL

References
Author Title Citation
Rhee, SY HIV-1 protease and reverse transcriptase mutations: Correlations with antiretroviral therapy in subtype B isolates and implications for drug-resistance surveillance. J Infect Dis, 2005