Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA1808 | CA33978 | U.S. | 2002 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 143 |
| 2 | DDI | 169 |
| 3 | D4T+3TC+IDV | 61 |
| 4 | 3TC+AZT+DDI+IDV | 8 |
| 5 | AZT+3TC+NVP+NFV | 78 |
| 6 | ABC+EFV+RTV+SQV | 22 |
| 7 | ABC+APV+D4T+DDI+RTV+SQV | 182 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54L, I84V, L90M | G73C | L10I, I13IM, I15V, K20I, M36I, R41K, I62V, L63P, I72L, I85V, I93L |
| >CA33978| codons 1-99 PQITLWQRPIVTMKVGGQLIEALLDTGADDTVLEEINLPGKWKPKIIGGIGGFLKVRQYD QVPIEICGHKALCTVLVGPTPVNVVGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, L74V, L210W, T215Y | D67G, K219N | L100LI, K101KE, K103KN, Y181YC | V108VI | E6ED, K20R, E28EK, E44D, S68G, V118I, K122KE, I135V, S162C, T200A, D218E, D237DE, V245T, A272P, K281R, T286A |
| >CA34994| codons 1-301 PISPIDTVPVKLKPGMDGPRVKQWPLTKEKIKALVEICTELEKDGKISKIGPENPYNTPV FAIKKKGGTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGIEKNKSVTILDVGDAYFSIPL DEDFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFRKQNPDIVI CQYMDDLYVGSDLEIGQHRAKIEELRQHLWRWGFYTPENKHQKEPPFLWMGYELHPEKWT VQPITLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCRLLRGAKALTEVIPLTEEAE L |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |