Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA1158 | CA33933 | U.S. | 2002 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 42 |
| 2 | AZT+DDI | 10 |
| 3 | 3TC+AZT+IDV | 44 |
| 4 | AZT+IDV+NVP | 9 |
| 5 | 3TC+AZT+NFV+SQV | 35 |
| 6 | None | 10 |
| 7 | ADV+DDI+EFV+RTV+SQV | 24 |
| 8 | NFV+SQV | 15 |
| 9 | None | 14 |
| 10 | 3TC+ADV+AZT+EFV | 25 |
| 11 | None | 58 |
| 12 | 3TC+D4T+EFV | 9 |
| 13 | 3TC+APV+D4T+DDI+LPV | 87 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54V, V82A, L90M | L23I, L33F, F53L | L10I, E35D, M36V, R57K, D60E, I62V, L63P, A71V, I93L |
| >CA33933| codons 1-99 PQITLWQRPIVTIKIGGQLKEAILDTGADDTVFEDVNLPGRWKPKMIGGIGGLVKVKQYE QVPIEICGHKVIGTVLVGPTPANIIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, L210W, T215Y | K103N, Y188L | P1L, K43N, K122E, E138A, I142V, S162C, R211Q, L228R, V245E, K277R, Q278H, I293V, E297A |
| >CA34949| codons 1-300 LISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELENEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSINNATPGVRYQYNVLPQGWKGSPAIFQCSMTKILEPFRKQNPDIVI YQYMDDLLVGSDLEIGQHRTKIEELRQHLWQWGFYTPDKKHQKEPPFRWMGYELHPDKWT VQPIELPEKDSWTVNDIQKLVGKLNWASQIYAGIKVRHLCKLLRGTKALTEVVPLTAEAE |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |