Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA4317 | CA33910 | U.S. | 2002 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT+DDC | 26 |
| 2 | D4T+DDI+IDV | 22 |
| 3 | 3TC+AZT+IDV | 43 |
| 4 | 3TC+AZT+IDV+NFV+NVP | 35 |
| 5 | 3TC+D4T+NFV | 130 |
| 6 | 3TC+AZT+NFV | 109 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54V, V82T | L24I | L10I, T12P, K14KR, K20Q, M36I, N37D, L63P, I64IV, A71V, I93L |
| >CA33910| codons 1-99 PQITLWQRPIVPIRIGGQLQEALIDTGADDTVLEEIDLPGRWKPKLIGGIGGFVKVRQYD QIPVEICGHKVIGTVLVGPTPTNIIGRNLLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, T69D, V75M, M184V, L210W, T215Y | F77L | K43KE, E44D, V118I, D123E, I135L, I142V, S162SN, Q174HN, V179I, T200A, Q207E, R211K, L228R, T286A, E297K |
| >CA34925| codons 1-300 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEEDGKISKIGPENPYNTPV FAIKKKDSDKWRKLMDLRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSIPL DKEFRKYTAFTIPSLNNETPGVRYQYNVLPQGWKGSPAIFQNSMTKILEPFRKHNPDIII YQYVDDLYVGSDLEIGQHRAKIEELREHLWKWGFYTPDKKHQKEPPFRWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGAKALTEVIPLTKEAE |
Integrase Sequence
| INIMajorDRMs | INIMinorDRMs | Polys | UnusualMuts |
| S17N, A23AV, L28I, S39C, I72V, S119P |
| >CA124183| codons 1-288 FLDGIDKAQEEHEKYHNNWRAMVSDFNIPPVVAKEIVACCDKCQLKGEAMHGQVDCSPGI WQLDCTHLEGKVILVAVHVASGYIEAEVIPAETGQETAYFLLKLAGRWPVKTIHTDNGPN FTSTTVKAACWWAGIKQEFGIPYNPQSQGVVESMNKELKKIIGQVRDQAEHLKTAVQMAV FIHNFKRKGGIGGYSAGERIVDIIATDIQTKELQKQITKIQNFRVYYRDSRDPLWKGPAK LLWKGEGAVVIQDNSDIKVVPRRKAKIIRDYGKQMAGDDCVASRQDED |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 protease and reverse transcriptase mutations: Correlations with antiretroviral therapy in subtype B isolates and implications for drug-resistance surveillance. | J Infect Dis, 2005 |