Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA14383 | CA33627 | U.S. | 2002 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 313 |
| 2 | DDI | 57 |
| 3 | AZT+DDI | 21 |
| 4 | 3TC+D4T+RTV | 61 |
| 5 | 3TC+D4T+IDV | 82 |
| 6 | 3TC+D4T+NVP+RTV+SQV | 212 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I84V, L90M | G73S | L10I, T12TA, I13V, K20KM, N37ND, L63P, A71V, I72IV, V77I, I93L |
| >CA33627| codons 1-99 PQITLWQRPIVAVKIGGQLMEALLDTGADDTVLEEMDLPGRWKPKIIGGIGGFIKVRQYD QIPIEICGHKVVSTVLIGPTPVNVIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, K70R, V75M, M184V, L210W, T215F | K219W | G190A | K101H | T39N, K43Q, V60I, V118I, K122E, I135T, I142V, G196E, H208Y, R211K, L228H, V245VE, A272AP, K277R, L283I, A288S, I293V, E297K, E312EA, G333E, G335S, R356RK, A360AT, A376AT, T377TM, S379C, K390R, A400T, T403AS, E404ED, V435E, A437AV, D460N, V466VI, T470P, H483HY, L491S, E516ED, Q524E, V548I, A554S |
| >CA34643| codons 1-560 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICNELEQEGKISKIGPENPYNTPI FAIKKKNSDRWRKLMDFRELNKRTQDFWEVQLGIPHPAGLHKKKSVTVLDVGDAYFSIPL DEDFRKYTAFTIPSTNNETPGVRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYVDDLYVASDLEIEQHRTKIEELRQYLWKWGFFTPDWKHQKEPPFHWMGYELHPDKWT VQPIELPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLIRGTKSLTEVVPLTKEAE LELAENREILKAPVHGVYYDPSKDLIAEIQKQEQSQWTYQIYQEPFKNLKTGKYAKMRGT HTNDVKQLTEAVQKITMECIVIWGKTPKFRLPIQKETWETWWSDYWQATWIPEWEFVNTP PLVKLWYQLEKEPIEGVETFYVDGAANRETKLGKAGYVTNRGRQKIVSLPDTTNQKTELQ AIYLALQDSGSEVNIVTDSQYALGIIQAQPDKSESDLVSQIIEELIKKEKVYLAWVPAHK GIGGNEQIDKLVSSGIRKVL |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |