<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
CA4908 CA33619 U.S. 2002 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 DDI 109
2 AZT+DDI 61
3 AZT+DDI+SQV 61
4 3TC+AZT+NVP 17
5 3TC+AZT+NFV 26
6 EFV+RTV+SQV 20
7 ABC+D4T+DDI 32
8 ABC+EFV+RTV+SQV 31
9 ABC+D4T+LPV 76

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
I54V, I84V, L90M L10F, V11I, Q58E, G73S I15V, G16A, K20I, L63P, A71V, I72IL, P79S, I85V, T91S  
>CA33619| codons 1-99
PQITLWQRPFITIKVAGQLIEALLDTGADDTVLEEMNLPGRWKPKMIGGIGGFVKVREYD
QIPIEICGHKVLSTVLVGSTPVNVVGRNLMSQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, L74IV, L210W, T215Y K219KR V106A, G190A V179D, F227L V35I, T39A, K43Q, V118I, D123E, K166KR, D177E, V189VI, G196E, R211K, D237DN, T286A, I293V, E297K  
>CA34634| codons 1-301
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALIEICAELEQEGKISKIGPENPYNTPV
FAIKKKNSTKWRKIVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSATVLDVGDAYFSIPL
DKEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTRILEPFRKQNPEIDI
YQYMDDLYIASDLEIEQHRTKIEELRQHLWKWGFYTPDRKHQKEPPLLWMGYELHPNKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGAKALTEVVPLTKEAE
L

References
Author Title Citation
Rhee, SY HIV-1 protease and reverse transcriptase mutations: Correlations with antiretroviral therapy in subtype B isolates and implications for drug-resistance surveillance. J Infect Dis, 2005
Rhee, SY Predictive value of HIV-1 genotypic resistance test interpretation algorithms. J Infect Dis, 2009