Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA2204 | CA33562 | U.S. | 2002 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT+DDI | 100 |
| 2 | AZT+DDI+NFV | 39 |
| 3 | 3TC+D4T+NVP | 87 |
| 4 | 3TC+D4T+IDV | 72 |
| 5 | 3TC+ABC+APV+D4T | 37 |
| 6 | APV+D4T+DDI+RTV | 43 |
| 7 | 3TC+APV+D4T+RTV+TDF | 18 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I84V, L90M | L10F, L33F, N88D | I15V, R41K, I62V, L63P, I66L, V77I, I93L, C95F |
| >CA33562| codons 1-99 PQITLWQRPFVTIKVGGQLKEALLDTGADDTVFEEMNLPGKWKPKIIGGIGGFIKVRQYD QVPIELCGHKAIGTVLIGPTPVNVIGRDLMTQLGFTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, M184V, L210W, T215Y | N348I | K103N | V35M, K43Q, E44D, D86N, V118I, E138Q, S162D, G196D, R211K, Q278H, T286A, I293V, E297R, K366R, S379G, K385KR, T386I, A400T, G436E, N447NS, D460N, V467I, L491S, S519ST, Q524E, A554T | K13N, Y127YC |
| >CA34577| codons 1-560 PISPIETVPVKLNPGMDGPKVKQWPLTEEKIKALMEICTELEQDGKISKIGPENPYNTPV FAIKKKNSTKWRKLVDFRELNKRTQNFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSIPL DKDFRKCTAFTIPSINNQTPGIRYQYNVLPQGWKGSPAIFQDSMTKILEPFRKQNPDIVI YQYVDDLYVGSDLEIDQHRTKIEELRQHLWKWGFYTPDKKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKHLCKLLRGAKALTEVVPLTREAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKILKTGKYARMRGA HTNDVRQLTEAVQKIATEGIVIWGRIPKFKLPIQKETWETWWTEYWQATWIPEWEFVNTP PLVKLWYQLEKEPIVEAETFYVDGAASRETKLGKAGYVTNRGRQKVISLTDTTNQKTELQ AIHLALQDSGSEVNIVTDSQYALGIIQAQPDKSESELVTQIIEELIKKEKVYLAWVPAHK GIGGNEQVDKLVSTGIRKVL |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |
| Rhee, SY | Predictive Value of HIV-1 Genotypic Resistance Test Interpretation Algorithms. | J Infect Dis, 2009 |