Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA4057 | CA33519 | U.S. | 2002 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 157 |
| 2 | 3TC+AZT+IDV | 22 |
| 3 | 3TC+ABC+ADV+APV+Unknown | 31 |
| 4 | 3TC+APV+Unknown | 196 |
| 5 | Unknown | 87 |
| 6 | 3TC+ABC+APV+LPV | 41 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54V, V82A | L10F, V11I, L24I, L89V | T12P, I13V, K20M, M36I, I62V, L63P, C67Y, A71V, I72M, I93L |
| >CA33519| codons 1-99 PQITLWQRPFIPVKIGGQLMEALIDTGADDTVLEEINLPGRWKPKLIGGIGGFVKVRQYD QVPIEIYGHKVMGTVLVGPTPANIIGRNVLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, L74V, M184V, L210W, T215Y | Y181C | V108I, F227L | P4PH, I5IV, K20R, V35L, T39TA, E44ED, K122E, I135T, I167IV, T200A, E203K, Q207E, R211RK, K223E, A272P, T286A, E297K |
| >CA34537| codons 1-302 PISHVETVPVKLKPGMDGPRVKQWPLTEEKIKALLEICAELEKDGKISKIGPENPYNTPV FAIKKKNSDKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTILDVGDAYFSVPL DEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKVLEPFRKQNPDIVI CQYVDDLYVGSDLEIGQHRAKIKELREHLWKWGFYTPDKKHQEEPPLLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGAKALTEVIPLTKEAE LE |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |