Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA4128 | CA33490 | U.S. | 2002 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | D4T | 13 |
| 2 | 3TC+D4T | 44 |
| 3 | 3TC+D4T+IDV | 26 |
| 4 | 3TC+D4T+NFV | 91 |
| 5 | D4T+RTV+SQV | 149 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| D30N, I54IL, I84V, L90LM | L10F, N88D | I13V, K20T, L33V, I64V, A71V |
| >CA33490| codons 1-99 PQITLWQRPFVTVKIGGQLTEALLDTGADNTVVEEMNLPGRWKPKMIGGIGGFLKVRQYD QILVEICGHKVIGTVLVGPTPVNVIGRDLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, L210W, T215Y | V35T, K43E, K102KE, V118VI, K122E, D123E, D177E, R211RK, V292VI, I293V |
| >CA34494| codons 1-300 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICTELEEEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKEKKSVTVLDVGDAYFSIPL DEEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPEIVI YQYMDDLYVGSDLEIGQHRTKIEELRQHLWKWGFYTPDKKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGTKALTEIVPLTEEAE |
References
| Author | Title | Citation |
| Mitsuya, Y | N88D facilitates the co-occurrence of D30N and L90M and the development of multidrug resistance in HIV type 1 protease following nelfinavir treatment failure. | ARHR, 2006 |