Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA9991 | CA33405 | U.S. | 2002 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | DDI | 48 |
| 2 | D4T | 65 |
| 3 | 3TC+AZT | 31 |
| 4 | 3TC+D4T+RTV | 83 |
| 5 | DDI+NFV+NVP | 26 |
| 6 | EFV+RTV+SQV | 8 |
| 7 | ABC+EFV+RTV+SQV | 82 |
| 8 | 3TC+ABC+D4T+DDI+LPV | 80 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54V, V82A, L90M | L10F | I15V, R57K, I62V, L63P, I64V, A71T, V77I |
| >CA33405| codons 1-99 PQITLWQRPFVTIKVGGQLKEALLDTGADDTVLEEMNLPGRWKPKLIGGIGGFVKVKQYD QVPVEICGHKTIGTVLIGPTPANIIGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, M184V, L210W, T215Y | K219E | K103N | V35K, T39A, E40F, K43E, K49R, I50V, V106I, I135L, S162C, T200TS, H208Y, R211K, L228H, K277R, A288T, I293V, E297K |
| >CA34421| codons 1-299 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALKEICAFLEEEGKISRVGPENPYNTPV FAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSITVLDVGDAYFSVPL DKDFRKYTAFTIPSLNNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFRKQNPDIVI YQYVDDLYVGSDLEIGQHRSKIEELRQYLWKWGFYTPDEKHQKEPPFHWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVRQLCKLLRGTKTLTEVVPLTKEA |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |