Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA596 | CA3338 | U.S. | 1998 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 52 |
| 2 | AZT+DDI | 52 |
| 3 | DDI | 222 |
| 4 | D4T | 17 |
| 5 | 3TC+D4T | 26 |
| 6 | 3TC+AZT | 48 |
| 7 | D4T+NFV | 26 |
| 8 | 3TC+AZT+SQV | 18 |
| 9 | 3TC+D4T+IDV | 50 |
| 10 | 3TC+D4T+RTV+SQV | 12 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I84V, L90M | L10I, K20I, E35D, M36I, I62V, L63P, I64V, G73X |
| >CA3338| codons 1-99 PQITLWQRPIVTIKIGGQLIEALLDTGADDTVLEDINLPGRWKPKIIGGIGGFIKVRQYD QVPVEICGHKAIXTVLVGPTPVNVIGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, M184V, L210LW, T215Y | E40X, K43EQ, V106VI, V118I, I135X, Q207X, H208HY, R211K | K220KE |
| >CA3337| codons 1-244 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTXLEQEGKISKIGPENPYNTPV FAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSITVLDVGDAYFSIPL DKDFRKYTAFTIPSXNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYVDDLYVGSDLEIGQHRTKIEELRXYLWKWGFYTPDKEHQKEPPFLWMGYELHPDKWT VQPI |
References
| Author | Title | Citation |
| Wu, TD | Mutation patterns and structural correlates in human immunodeficiency virus type 1 protease following different protease inhibitor treatments. | J Virol, 2003 |
| Gonzales, MJ | Protease and reverse transcriptase mutation patterns in HIV-1 isolates from heavily treated persons: comparison of isolates from northern California with isolates from other regions. | ARHR, 2003 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |