<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
CA1137 CA33379 U.S. 2002 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 AZT 104
2 None 31
3 DDC 135
4 D4T 22
5 D4T+DDI 17
6 3TC+D4T+SQV 26
7 3TC+AZT+IDV 26
8 3TC+AZT 22
9 3TC+AZT+RTV+SQV 32
10 3TC+AZT 81
11 None 7
12 ABC+APV+EFV+RTV 6
13 ABC+APV+DLV+RTV 3
14 ABC+APV+DLV 97

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I54M, L76V Q58E L10I, L63P  
>CA33379| codons 1-99
PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEEMNLPGRWKPKIIGGIGGFMKVREYD
QIPIEICGHKAIGTVVVGPTPVNIIGRNLLTQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, L74V, Y115F, T215Y K219KN K103N, Y181C   T39A, V90I, K122E, T139TA, S162A, I202IV, A272P, K277KR, Q278H  
>CA34391| codons 1-301
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICAELEKEGKISKIGPENPYNTPV
FAIKKKDSTKWRKVVDFRELNKRTQDFWEIQLGIPHPAGLKKNKSVTVLDVGDAFFSVPL
DEDFRKYTAFTIPSINNEAPGIRYQYNVLPQGWKGSPAIFQASMTKILEPFRKQNPDIVI
CQYMDDLYVGSDLEIGQHRTKVEELRQHLLRWGFYTPDNKHQKEPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRHLCKLLRGTKALTEVIPLTEEAE
L

References
Author Title Citation
Rhee, SY HIV-1 protease and reverse transcriptase mutations: Correlations with antiretroviral therapy in subtype B isolates and implications for drug-resistance surveillance. J Infect Dis, 2005