Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA14192 | CA33304 | U.S. | 2002 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT+DDC | 48 |
| 2 | D4T+DDI | 17 |
| 3 | AZT | 39 |
| 4 | 3TC+AZT+IDV | 35 |
| 5 | D4T+DDI+NVP | 26 |
| 6 | D4T+DDI+NFV | 35 |
| 7 | 3TC+RTV+SQV | 57 |
| 8 | 3TC+ABC+EFV+RTV+SQV | 158 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| L90M | G73S | L10I, K14R, K20V, L63P, A71IV, V77I, I93L |
| >CA33304| codons 1-99 PQITLWQRPIVTIRIGGQLVEALLDTGADDTVLEEMNLPGRWKPKMIGGIGGFIKVRQYD QIPIEICGHKIISTVLIGPTPVNIIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, T69D, L74I, L210W, T215Y | K219R | Y181C, G190S | T7TA, K11R, V21I, K43E, E44A, R83K, K101Q, V118I, K122E, R172K, D177E, V179I, G196E, R211K, D218E, L228R, T286P, A288S, I293V, E297R |
| >CA34319| codons 1-301 PISPIEAVPVRLKPGMDGPKIKQWPLTEEKIKALVEICTELEEAGKISKIGPENPYNTPV FAIKKKDSDKWRKIVDFRELNKKTQDFWEVQLGIPHPAGLQKKKSVTVLDVGDAYFSIPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFKKQNPEIII CQYMDDLYVSSDLEIEQHRTKIEELRQHLWKWGFYTPERKHQKEPPFRWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGPKSLTEVVPLTREAE L |
References
| Author | Title | Citation |
| Rhee, SY | Distribution of human immunodeficiency virus type 1 protease and reverse transcriptase mutation patterns in 4,183 persons undergoing genotypic resistance testing. | AAC, 2004 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |