Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| M64940 | M64940 | U.K. | 2002 | HIV1 | G | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 104 |
| 2 | 3TC+ IDV+ D4T | 134 |
| 3 | D4T+ DDI+ NVP+ NFV | 69 |
| 4 | ABC+ DDI+ LPV | 90 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| G48A, I54V, V82S, L90M | L89V | L10I, I13A, K14R, K20I, M36I, N37D, R41K, L63P, H69K, A71V |
| >M64940| codons 1-99 PQITLWQRPIVTARIGGQLIEALLDTGADDTVLEEIDLPGKWKPKMIAGIGGFVKVRQYD QIPIEICGKKVIGTVLVGPTPSNIIGRNVMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, T69D, K70R, T215F | K219Q | A98G | E6S, K11T, K20R, V35T, V60I, L109I, K122E, D123S, K173T, D177E, G196E, T200A, I202V, Q207E, R211K, L228H, V245Q, E248D, D250E, A272P, E291D, V292I, I293V, E297T, D324E |
| >M64940| codons 1-335 PISPISTVPVTLKPGMDGPRVKQWPLTEEKIKALTEICTEMEKEGKISKIGPENPYNTPI FAIKKKNSDRWRKLVDFRELNKRTQDFWEVQLGIPHPGGLKKKKSVTVIDVGDAYFSVPL DESFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRTQNPEIVI YQYMDDLYVGSDLEIEQHRAKVEELREHLLKWGFFTPDQKHQKEPPFHWMGYELHPDKWT VQPIQLPDKESWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTDIVPLTTEAE LELAENREILKEPVHGVYYDPSKELIAEIQKQGQG |
References
| Author | Title | Citation |
| Weber, J | Impact of HIV-1 subtype and antiretroviral therapy on protease and reverse transcriptase genotype: Results of a global collaboration. | PLoS Med, 2005 |