Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA1321 | CA3317 | U.S. | 1998 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT+ 3TC | 143 |
| 2 | 3TC+ D4T+ RTV+ SQV | 31 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I84V, L90LM | L24LI, L33LF, K43KT, F53FL, T74TP | L10LV, I13V, K20KR, A22AV, E35D, M36I, N37ND, I62V, L63P, A71AV, T91TA |
| >CA3317| codons 10-99 VVTVKIGGQLREVLIDTGADDTVFEDIDLPGRWTPKIIGGIGGLIKVRQYDQVPIEICGH KVIGPVLVGPTPVNVIGRNLMAQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, K70R, L74I, M184V, T215Y | K219Q | K20R, V35I, A98S, D123E, I135V, S162D, I178L, H208Y, R211RK, K277R |
| >CA3316| codons 1-300 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALIEICTELEKEGKISKIGPENPYNTPV FAIKKKNSTRWRKIVDFRELNKRTQDFWEVQLGIPHPSGLKKKKSVTVLDVGDAYFSVPL DKEFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSPAIFQDSMTKILEPFRKQNPDLVI YQYVDDLYVGSDLEIGQHRTKIEELRQYLLKWGFYTPDQKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVRQLCKLLRGTKALTEVIPLTEEAE |
References
| Author | Title | Citation |
| Gonzales, MJ | HIV-1 reverse transcriptase and protease subtypes: Classification, amino acid mutation patterns, and prevalence in a northern California clinic-based population. | J Infect Dis, 2001 |
| Rhee, SY | HIV-1 protease and reverse transcriptase mutations: Correlations with antiretroviral therapy in subtype B isolates and implications for drug-resistance surveillance. | J Infect Dis, 2005 |