Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| F45753 | F45753 | U.K. | 2002 | HIV1 | A | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 28 |
| 2 | SQV+ 3TC+ D4T | 92 |
| 3 | NFV+ DDI+ D4T | 166 |
| 4 | 3TC+ AZT+ ABC | 55 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| L10I, I13V, G16E, K20R, E35D, M36I, P39S, R41K, H69K, L89M |
| >F45753| codons 1-99 PQITLWQRPIVTVKIEGQLREALLDTGADDTVLEDINLSGKWKPKMIGGIGGFIKVRQYD QILIEICGKKAIGTVLVGPTPVNIIGRNMLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, M184V, L210W, T215Y | K11T, K20R, V21I, V35T, T39S, E44ED, V60I, D121H, K122E, D123S, D177E, V179I, T200A, I202V, Q207A, V245K, D250E, S251H, T286A, E291D, V292I, I293V, P294T, E312D |
| >F45753| codons 1-334 PISPIETVPVTLKPGMDGPRIKQWPLTEEKIKALTEICSELEKDGKISKIGPENPYNTPI FAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL HESFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPEIII YQYVDDLYVGSDLEIGQHRAKVEELRAHLWRWGFYTPDKKHQKEPPFLWMGYELHPDKWT VQPIKLPEKEHWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGAKALTDIVTLTEEAE LELAENREILKDPVHGVYYDPSKDLIAEIQKQGQ |
References
| Author | Title | Citation |
| Weber, J | Impact of HIV-1 subtype and antiretroviral therapy on protease and reverse transcriptase genotype: Results of a global collaboration. | PLoS Med, 2005 |