Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| SWC-9877 | 9877-2872 | U.S. | 2000 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 70 |
| 2 | AZT+ DDC | 36 |
| 3 | 3TC | 32 |
| 4 | 3TC+ DDI+ IDV | 38 |
| 5 | D4T+ SQV | 7 |
| 6 | DDC+ RTV+SQV | 12 |
| 7 | AZT+ NFV+ NVP | 28 |
| 8 | 3TC+ D4T+ IDV+ NVP | 61 |
| 9 | NVP+ IDV+ 3TC+ D4T+ APV+ DDI+ ABC | 1 |
| 10 | APV+ DDI+ ABC | 34 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I84V, L90M | L33F, G73T | L10I, E34Q, N37D, I62V, L63P, V77I, I93L |
| >9877-2872| codons 1-99 PQITLWQRPIVTIKIGGQLKEALLDTGADDTVFQEMDLPGRWKPKLIGGIGGFIKVRQYD QVPIEICGHKAITTVLIGPTPVNVIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, M184MI, L210W, T215Y | K103N, Y181C | T27P, V35T, T39S, E44D, K122KE, I135T, S162A, D177E, I178L, V179VI, T200A, E203K, Q207E, R211K, K223E |
| >9877-2872| codons 21-260 VKQWPLPEEKIKALTEICSELEKDGKISKIGPENPYNTPVFAIKKKNSTKWRKLVDFREL NKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPLDEDFRKYTAFTIPSTNNETP GIRYQYNVLPQGWKGSPAIFQASMTKILEPFRKQNPELIICQYIDDLYVGSDLEIGQHRA KIKELREHLWKWGFYTPDKKHQEEPPFLWMGYELHPDKWTVQPIVLPEKDSWTVNDIQKL |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |