Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| SWC-9877 | 9877-2208 | U.S. | 1999 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 70 |
| 2 | AZT+ DDC | 36 |
| 3 | 3TC | 32 |
| 4 | 3TC+ DDI+ IDV | 38 |
| 5 | D4T+ SQV | 7 |
| 6 | DDC+ RTV+SQV | 12 |
| 7 | AZT+ NFV+ NVP | 28 |
| 8 | 3TC+ D4T+ IDV+ NVP | 60 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I84V, L90M | G73S | L10I, N37D, I62V, L63P, A71V, V77I, I93L, F99FL |
| >9877-2208| codons 1-99 PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEEMDLPGRWKPKIIGGIGGFIKVRQYD QVPIEICGHKVISTVLIGPTPVNVIGRNLMTQLGCTLNL |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, M184I, L210W, T215Y | K103N, Y181C | V35T, T39S, E44D, I135T, S162A, K166R, D177E, I178L, T200A, E203K, Q207E, R211K, K223E, A272P | Q269QH |
| >9877-2208| codons 22-273 KQWPLTEEKIKALTEICSELEKDGKISKIGPENPYNTPVFAIKKKNSTKWRKLVDFRELN KRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPLDKDFRKYTAFTIPSTNNETPG IRYQYNVLPQGWKGSPAIFQASMTRILEPFRKQNPELVICQYIDDLYVGSDLEIGQHRAK IKELREHLWKWGFYTPDKKHQEEPPFLWMGYELHPDKWTVQPIVLPEKDSWTVNDIQKLV GKLNWASHIYPG |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 protease and reverse transcriptase mutations: Correlations with antiretroviral therapy in subtype B isolates and implications for drug-resistance surveillance. | J Infect Dis, 2005 |