Isolate Data
Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
SWC-9877 | 9877-2208 | U.S. | 1999 | HIV1 | B | Plasma | None |
Treatment History
Order | Regimen | Weeks |
1 | AZT | 70 |
2 | AZT+ DDC | 36 |
3 | 3TC | 32 |
4 | 3TC+ DDI+ IDV | 38 |
5 | D4T+ SQV | 7 |
6 | DDC+ RTV+SQV | 12 |
7 | AZT+ NFV+ NVP | 28 |
8 | 3TC+ D4T+ IDV+ NVP | 60 |
Protease Sequence
PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
M46I, I84V, L90M | G73S | L10I, N37D, I62V, L63P, A71V, V77I, I93L, F99FL |
>9877-2208| codons 1-99 PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEEMDLPGRWKPKIIGGIGGFIKVRQYD QVPIEICGHKVISTVLIGPTPVNVIGRNLMTQLGCTLNL |
RT Sequence
NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
M41L, D67N, M184I, L210W, T215Y | K103N, Y181C | V35T, T39S, E44D, I135T, S162A, K166R, D177E, I178L, T200A, E203K, Q207E, R211K, K223E, A272P | Q269QH |
>9877-2208| codons 22-273 KQWPLTEEKIKALTEICSELEKDGKISKIGPENPYNTPVFAIKKKNSTKWRKLVDFRELN KRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPLDKDFRKYTAFTIPSTNNETPG IRYQYNVLPQGWKGSPAIFQASMTRILEPFRKQNPELVICQYIDDLYVGSDLEIGQHRAK IKELREHLWKWGFYTPDKKHQEEPPFLWMGYELHPDKWTVQPIVLPEKDSWTVNDIQKLV GKLNWASHIYPG |
References
Author | Title | Citation |
Rhee, SY | HIV-1 protease and reverse transcriptase mutations: Correlations with antiretroviral therapy in subtype B isolates and implications for drug-resistance surveillance. | J Infect Dis, 2005 |