Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| SWC-9447 | 9447-2329 | U.S. | 1999 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 54 |
| 2 | DDC | 49 |
| 3 | D4T | 10 |
| 4 | NRTI | 42 |
| 5 | 3TC+ AZT | 22 |
| 6 | 3TC+ DDC+ IDV | 18 |
| 7 | 3TC+ NVP+ SQV+ AZT | 27 |
| 8 | 3TC+ NVP+ SQV+ AZT+ NFV | 11 |
| 9 | 3TC+ SQV+ NFV+ RTV+ DDC | 2 |
| 10 | DDC+ RTV+ SQV | 29 |
| 11 | DDC | 13 |
| 12 | 3TC+ AZT | 6 |
| 13 | Unknown | 44 |
| 14 | EFV+ ABC | 6 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, M184V, L210W, T215Y | V179D | K103R, K122E, S162C, T200A, D218E |
| >9447-2329| codons 30-232 KIKALVEICTELEKEGKISKIGPENPYNTPVFAIKKKNSTKWRKLVDFRELNKRTQDFWE VQLGIPHPAGLKKRKSVTVLDVGDAYFSVPLDEDFRKYTAFTIPSINNETPGIRYQYNVL PQGWKGSPAIFQCSMTKILEPFRKQNPDIDIYQYVDDLYVGSDLEIGQHRAKIEELRQHL WRWGFYTPEKKHQKEPPFLWMGY |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| Q61E, I62V, L63P, V77I, I93L |
| >9447-2329| codons 1-99 PQITLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMNLPGRWKPKMIGGIGGFIKVRQYD EVPIEICGHKAIGTVLIGPTPVNIIGRNLLTQLGCTLNF |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |