Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| SWC-8546 | 8546-3725 | U.S. | 2001 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 237 |
| 2 | AZT+ DDC | 55 |
| 3 | 3TC+ AZT | 21 |
| 4 | 3TC+ AZT+ DDC | 19 |
| 5 | 3TC+ AZT | 13 |
| 6 | 3TC+ IDV+ D4T | 27 |
| 7 | IDV+ D4T | 50 |
| 8 | 3TC+ D4T | 97 |
| 9 | APV+ RTV+ D4T | 37 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| T69DN, K70R | D67DG, T215V, K219Q | V35VI, K64H, A98S, V118I, K122KE, V179IT, T200E, F214L |
| >8546-3725| codons 21-260 VKQWPLTEEKIKALIEICTEMEKEGKISKIGPENPYNTPVFAIHKKGSNRWRKLVDFREL NKRTQDFWEVQLGIPHPSGLKKKKSVTVLDVGDAYFSIPLDEDFRKYTAFTIPSINNETP GIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDITIYQYMDDLYVGSDLEIGQHRE KIEELRQHLLRWGLVTPDQKHQKEPPFLWMGYELHPDKWTVQPIVLPEKDSWTVNDIQKL |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I47V, I54M | L33F, G73C | L10LV, R57K, L63P |
| >8546-3725| codons 1-99 PQITLWQRPVVTIKIGGQLKEALLDTGADDTVFEEMNLPGRWKPKIVGGIGGFMKVKQYD QIPIEICGHKAICTVLVGPTPVNIIGRNLLTQIGCTLNF |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |