Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| SWC-7463 | 7463-3632 | U.S. | 2000 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | Unknown | NA |
| 2 | IDV+ D4T+ 3TC | 142 |
| 3 | D4T+ 3TC | 2 |
| 4 | 3TC | 1 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, G48V, I54A, V82A, L90M | L10I, D60E, Q61E, I62V, L63P, A71V, I72V, V77I, I93L |
| >7463-3632| codons 1-99 PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEEMNLPGRWKPKLIVGIGGFAKVRQYE EVPIEICGHKVVGTVLIGPTPANIIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, M184V, L210W, T215Y | K32E, T39A, K43KQ, E44ED, V60VI, V118VI, I135T, I142IV, D177AG, T200AE, E203EK, H208HY, R211K, K223EQ, L228R |
| >7463-3632| codons 21-260 VKQWPLTEEKIEALVEICAELEQDGKISKIGPENPYNTPIFAIKKKDSTKWRKLVDFREL NKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSIPLDKDFRKYTAFTIPSTNNETP GVRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPGIVIYQYVDDLYVGSDLEIGQHRE KIKELRQYLWKWGFYTPDKKHQQEPPFRWMGYELHPDKWTVQPIVLPEKDSWTVNDIQKL |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |