Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| SWC-6459 | 6459-2425 | U.S. | 1999 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | 3TC+ D4T+ IDV | 14 |
| 2 | 3TC+ NFV+ NVP | 22 |
| 3 | 3TC+ NVP+ DDI+ NFV | 48 |
| 4 | 3TC+ NVP+ DDI+ NFV | 7 |
| 5 | 3TC+ NVP+ DDI+ NFV | 14 |
| 6 | 3TC+ DDI+ NFV | 5 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, K70R, M184V | K219E | Y181C | V35A, K49R, V60I, I135V, E169D, R211K, D218E, A272P |
| >6459-2425| codons 22-273 KQWPLTEEKIKALAEICTEMEKEGKISRIGPENPYNTPIFAIKKKNSTRWRKLVDFRELN KRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPLDKDFRKYTAFTIPSVNNETPG IRYQYNVLPQGWKGSPAIFQSSMTKILDPFRKQNPDIVICQYVDDLYVGSDLEIGQHRTK IEELRQHLLKWGFTTPEEKHQKEPPFLWMGYELHPDKWTVQPIVLPEKDSWTVNDIQKLV GKLNWASQIYPG |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, N88S | L19I, R41K, V77I, Q92X |
| >6459-2425| codons 1-99 PQITLWQRPLVTIKIGGQIKEALLDTGADDTVLEEMNLPGKWKPKIIGGIGGFIKVRQYD QILIEICGHKAIGTVLIGPTPVNIIGRSLLTHIGCTLNF |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |