Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| SWC-6100 | 6100-4969 | U.S. | 2002 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | DDC | 43 |
| 2 | NRTI | 87 |
| 3 | 3TC+ D4T | 89 |
| 4 | RTV+ DDI+ NVP+ SQV | 19 |
| 5 | DDI+ NVP+ SQV | 13 |
| 6 | DDI+ NVP+ SQV+ RTV | 15 |
| 7 | SQV+ RTV | 12 |
| 8 | SQV+ RTV+ NVP+ DDI | 1 |
| 9 | SQV+ RTV+ DDI | 9 |
| 10 | SQV+ RTV+ DDI+ NVP | 22 |
| 11 | SQV+ DDI+ NVP | 6 |
| 12 | DDI+ NVP | 6 |
| 13 | NVP | 3 |
| 14 | SQV+ RTV | 2 |
| 15 | SQV+ RTV+ ABC+ APV+ D4T | 1 |
| 16 | RTV+ ABC+ APV+ D4T | 4 |
| 17 | RTV | 1 |
| 18 | Unknown | 49 |
| 19 | EFV+ 3TC+ D4T | 38 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| E35D, N37E, P39S, R57K, I62V, L63S, I64L, A71V, V77I, I93L |
| >6100-4969| codons 1-99 PQITLWQRPLVTIKIGGQLKEALLDTGADDTVLEDMELSGRWKPKMIGGIGGFIKVKQYD QVSLEICGHKVIGTVLIGPTPVNIIGRNLLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| T69D, Q151M, M184V | F116Y | V106VA | V179D, P225H | V118I, K122E, I178L, I202V, R211K, F214L |
| >6100-4969| codons 23-260 QWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPVFAIKKKDSDKWRKLVDFRELNK RTQDFWEVQLGIPHPAGLKKKKSATVLDVGDAYYSIPLDEDFRKYTAFTIPSINNETPGI RYQYNVLPMGWKGSPAIFQSSMTKILEPFRKQNPDLDIYQYVDDLYVGSDLEIGQHRTKV EELRQHLLKWGLTTPDKKHQKEHPFLWMGYELHPDKWTVQPIVLPEKDSWTVNDIQKL |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |