<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
SWC-6100 6100-4969 U.S. 2002 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 DDC 43
2 NRTI 87
3 3TC+ D4T 89
4 RTV+ DDI+ NVP+ SQV 19
5 DDI+ NVP+ SQV 13
6 DDI+ NVP+ SQV+ RTV 15
7 SQV+ RTV 12
8 SQV+ RTV+ NVP+ DDI 1
9 SQV+ RTV+ DDI 9
10 SQV+ RTV+ DDI+ NVP 22
11 SQV+ DDI+ NVP 6
12 DDI+ NVP 6
13 NVP 3
14 SQV+ RTV 2
15 SQV+ RTV+ ABC+ APV+ D4T 1
16 RTV+ ABC+ APV+ D4T 4
17 RTV 1
18 Unknown 49
19 EFV+ 3TC+ D4T 38

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
T69D, Q151M, M184V F116Y V106VA V179D, P225H V118I, K122E, I178L, I202V, R211K, F214L  
>6100-4969| codons 23-260
QWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPVFAIKKKDSDKWRKLVDFRELNK
RTQDFWEVQLGIPHPAGLKKKKSATVLDVGDAYYSIPLDEDFRKYTAFTIPSINNETPGI
RYQYNVLPMGWKGSPAIFQSSMTKILEPFRKQNPDLDIYQYVDDLYVGSDLEIGQHRTKV
EELRQHLLKWGLTTPDKKHQKEHPFLWMGYELHPDKWTVQPIVLPEKDSWTVNDIQKL

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
    E35D, N37E, P39S, R57K, I62V, L63S, I64L, A71V, V77I, I93L  
>6100-4969| codons 1-99
PQITLWQRPLVTIKIGGQLKEALLDTGADDTVLEDMELSGRWKPKMIGGIGGFIKVKQYD
QVSLEICGHKVIGTVLIGPTPVNIIGRNLLTQLGCTLNF

References
Author Title Citation
Rhee, SY HIV-1 protease and reverse transcriptase mutations: Correlations with antiretroviral therapy in subtype B isolates and implications for drug-resistance surveillance. J Infect Dis, 2005