Isolate Data
Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
SWC-6100 | 6100-3787 | U.S. | 2001 | HIV1 | B | Plasma | None |
Treatment History
Order | Regimen | Weeks |
1 | DDC | 43 |
2 | NRTI | 87 |
3 | 3TC+ D4T | 89 |
4 | RTV+ DDI+ NVP+ SQV | 19 |
5 | DDI+ NVP+ SQV | 13 |
6 | DDI+ NVP+ SQV+ RTV | 15 |
7 | SQV+ RTV | 12 |
8 | SQV+ RTV+ NVP+ DDI | 1 |
9 | SQV+ RTV+ DDI | 9 |
10 | SQV+ RTV+ DDI+ NVP | 22 |
11 | SQV+ DDI+ NVP | 6 |
12 | DDI+ NVP | 6 |
13 | NVP | 3 |
14 | SQV+ RTV | 2 |
15 | SQV+ RTV+ ABC+ APV+ D4T | 1 |
16 | RTV+ ABC+ APV+ D4T | 4 |
17 | RTV | 1 |
18 | Unknown | 14 |
RT Sequence
NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
V179D | V35VI, I50V, V90VI, K122E, A158S, I202V, R211K, F214L |
>6100-3787| codons 21-260 VKQWPLTEEKIKALIEICTEMEKEGKISKVGPENPYNTPVFAIKKKDSTKWRKLVDFREL NKRTQDFWEIQLGIPHPAGLKKKKSVTVLDVGDAYFSVPLDEDFRKYTAFTIPSINNETP GIRYQYNVLPQGWKGSPSIFQSSMTKILEPFRKQNPDIDIYQYMDDLYVGSDLEIGQHRT KVEELRQHLLKWGLTTPDKKHQKEPPFLWMGYELHPDKWTVQPIVLPEKDSWTVNDIQKL |
Protease Sequence
PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
I54IV, I84IV | Q58QE | L10LI, K20KR, E35ED, M36MI, N37X, R57RK, I62IV, L63P, I64IV, A71AITV, V77VI |
>6100-3787| codons 1-92 PQITLWQRPIVTIKIGGQLREALLDTGADDTVLEDIXLPGRWKPKMIGGIGGFVKVKEYD QVPVEICGHKVIGTVLIGPTPVNVIGRNLLTQ |
References
Author | Title | Citation |
Rhee, SY | HIV-1 protease and reverse transcriptase mutations: Correlations with antiretroviral therapy in subtype B isolates and implications for drug-resistance surveillance. | J Infect Dis, 2005 |