Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| SWC-6100 | 6100-2671 | U.S. | 1999 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | DDC | 43 |
| 2 | NRTI | 87 |
| 3 | 3TC+ D4T | 89 |
| 4 | RTV+ DDI+ NVP+ SQV | 19 |
| 5 | DDI+ NVP+ SQV | 13 |
| 6 | DDI+ NVP+ SQV+ RTV | 15 |
| 7 | SQV+ RTV | 12 |
| 8 | SQV+ RTV+ NVP+ DDI | 1 |
| 9 | SQV+ RTV+ DDI | 9 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| T69D, Q151M | F77FL, F116Y | Y181C | V118I, K122E, A158S, I202V, R211K, F214L, A272P |
| >6100-2671| codons 21-273 VKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPVFAIKKKDSDKWRKLVDLREL NKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYYSIPLDEDFRKYTAFTIPSINNETP GIRYQYNVLPMGWKGSPSIFQSSMTKILEPFRKQNPDIVICQYMDDLYVGSDLEIGQHRT KVEELRQHLLKWGLTTPDKKHQKEPPFLWMGYELHPDKWTVQPIVLPEKDSWTVNDIQKL VGKLNWASQIYPG |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| E35D, M36I, N37E, I62V, L63P, A71T, V77I, I93L |
| >6100-2671| codons 1-99 PQITLWQRPLVTIKIGGQLKEALLDTGADDTVLEDIELPGRWKPKMIGGIGGFIKVRQYD QVPIEICGHKTIGTVLIGPTPVNIIGRNLLTQLGCTLNF |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |