Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| SWC-5577 | 5577-4533 | U.S. | 2001 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT+ D4T | 76 |
| 2 | 3TC+ DDC+ IDV | 44 |
| 3 | DDC+ RTV+ SQV | 29 |
| 4 | SQV | 3 |
| 5 | DDI+ NFV+ NVP | 41 |
| 6 | DDI+ NFV+ NVP+ IDV+ 3TC+ AZT | 4 |
| 7 | NVP+ IDV+ 3TC+ AZT | 6 |
| 8 | IDV+ 3TC+ AZT | 88 |
| 9 | 3TC+ AZT | 5 |
| 10 | 3TC+ AZT+ APV | 38 |
| 11 | 3TC+ AZT+ APV+ RTV | 21 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54M, I84V, L90M | L33F, G73T | L10I, I13V, K14R, R41K, I62V, L63P, I66IL, C67CF, V77I, I93L |
| >5577-4533| codons 1-99 PQITLWQRPIVTVRIGGQLKEALLDTGADDTVFEEMNLPGKWKPKIIGGIGGFMKVRQYD QVPIELFGHKAITTVLIGPTPVNVIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74V, M184V, L210W, T215Y | Y181C, G190A | K43Q, E44D, K101Q, V118I, K122E, I135V, I142V, S162C, T200A, E203D, Q207D, H208Y, R211K, H221Y, V245E, E248D |
| >5577-4533| codons 23-260 QWPLTEEKIKALVEICTELEQDGKISKIGPENPYNTPVFAIKKKNSTKWRKVVDFRELNK RTQDFWEVQLGIPHPAGLQKKKSVTVLDVGDAYFSIPLDEDFRKYTAFTIPSVNNETPGV RYQYNVLPQGWKGSPAIFQCSMTKILEPFRKQNPDIVICQYVDDLYVASDLEIGQHRAKI DELRDYLWKWGFYTPDKKYQKEPPFLWMGYELHPDKWTVQPIELPDKDSWTVNDIQKL |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |