<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
SWC-5577 5577-2204 U.S. 1999 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 AZT+ D4T 76
2 3TC+ DDC+ IDV 44
3 DDC+ RTV+ SQV 29
4 SQV 3
5 DDI+ NFV+ NVP 41
6 DDI+ NFV+ NVP+ IDV+ 3TC+ AZT 4
7 NVP+ IDV+ 3TC+ AZT 6
8 IDV+ 3TC+ AZT 22

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
I84V, L90M G73T L10I, K14R, N37Y, R41K, I62V, L63P, V77I, I93L  
>5577-2204| codons 1-99
PQITLWQRPIVTIRIGGQLKEALLDTGADDTVLEEMYLPGKWKPKMIGGIGGFIKVRQYD
QVPIEICGHKAITTVLIGPTPVNVIGRNLMTQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, L74V, M184V, L210W, T215Y   K101K*EQ, K103KN, Y181C, G190A V108I E44D, K122E, I135V, S162C, E203D, Q207D, R211K, H221Y, V245E, E248D F116FL, R172RS
>5577-2204| codons 22-258
KQWPLTEEKIKALVEICTELEKDGKISKIGPENPYNTPVFAIKKKDSTKWRKVVDFRELN
KRTQDFWEVQLGIPHPAGLQKNKSVTILDVGDAYLSVPLDEDFRKYTAFTIPSVNNETPG
IRYQYNVLPQGWKGSPAIFQCSMTKILEPFSKQNPDIVICQYVDDLYVASDLEIGQHRTK
IDELRDHLWKWGFYTPDKKYQKEPPFLWMGYELHPDKWTVQPIELPDKDSWTVNDIQ

References
Author Title Citation
Rhee, SY HIV-1 protease and reverse transcriptase mutations: Correlations with antiretroviral therapy in subtype B isolates and implications for drug-resistance surveillance. J Infect Dis, 2005