Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| SWC-5550 | 5550-2063 | U.S. | 1999 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | 3TC+ AZT+ IDV | 29 |
| 2 | D4T+ DDI+ SQV | 26 |
| 3 | DDC+ NFV+ NVP | 7 |
| 4 | NFV+ NVP+ DDC+ DDI | 1 |
| 5 | NFV+ NVP+ DDC | 7 |
| 6 | IDV+ 3TC+ AZT | 55 |
| 7 | DDI+ NFV+ EFV | 12 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I84V, L90M | L10F | K20M, E35D, M36I, N37S, K45R, L63P, I64V, L89M, I93X |
| >5550-2063| codons 1-99 PQITLWQRPFVTIKIGGQLMEALLDTGADDTVLEDISLPGRWKPRMIGGIGGFIKVRQYD QIPVEICGHKAIGTVLVGPTPVNVIGRNMMTQXGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| L74V | K103N, Y181C | V108I | V118I, K122E, D123N, Q197K, R211K, F214L, H221Y, L228H |
| >5550-2063| codons 21-233 VKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPVFAIKKKDSTKWRKVVDFREL NKRTQDFWEVQLGIPHPAGLKKNKSVTILDVGDAYFSIPLDENFRKYTAFTIPSINNETP GIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVICQYMDDLYVGSDLEIGKHRT KIEELRQHLLKWGLTTPDKKYQKEPPFHWMGYE |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |