Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| SWC-5550 | 5550-951 | U.S. | 1997 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | 3TC+ AZT+ IDV | 29 |
| 2 | D4T+ DDI+ SQV | 26 |
| 3 | DDC+ NFV+ NVP | 7 |
| 4 | NFV+ NVP+ DDC+ DDI | 1 |
| 5 | NFV+ NVP+ DDC | 7 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I84V | L10F, L23LIV | E35D, M36I, N37S, K45R, L63P |
| >5550-951| codons 1-88 PQITLWQRPFVTIKIGGQLKEAVLDTGADDTVLEDISLPGRWKPRMIGGIGGFIKVRQYD QIPIEICGHKAIGTVLVGPTPVNVIGRN |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| K65R | V75S | K103N, Y181C | V108I | V118I, K122E, D123N, Q197K, R211K, F214L, L228H | L187LF |
| >5550-951| codons 21-233 VKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPVFAIKRKDSTKWRKLSDFREL NKRTQDFWEVQLGIPHPAGLKKNKSVTILDVGDAYFSIPLDENFRKYTAFTIPSINNETP GIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVICQYMDDFYVGSDLEIGKHRT KIEELRQHLLKWGLTTPDKKHQKEPPFHWMGYE |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 protease and reverse transcriptase mutations: Correlations with antiretroviral therapy in subtype B isolates and implications for drug-resistance surveillance. | J Infect Dis, 2005 |