Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| SWC-4603 | 4603-4823 | U.S. | 2002 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 211 |
| 2 | AZT+ DDC | 118 |
| 3 | AZT | 59 |
| 4 | AZT+ EFV+ 3TC | 15 |
| 5 | EFV+ 3TC+ AZT+ NVP | 1 |
| 6 | 3TC+ AZT+ NVP | 1 |
| 7 | 3TC+ AZT | 113 |
| 8 | APV+ D4T+ 3TC | 1 |
| 9 | D4T+ 3TC | 2 |
| 10 | D4T+ 3TC+ NFV | 28 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| D30N | G16E, E35D, M36MI, L63T, I64V |
| >4603-4823| codons 1-99 PQITLWQRPLVTIKIEGQLKEALLDTGADNTVLEDINLPGRWKPKMIGGIGGFIKVRQYD QITVEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, M184V, L210W, T215Y | K103N | K43Q, A98S, I135T, T200A |
| >4603-4823| codons 21-260 VKQWPLTEEKIKALVEICTELEQEGKISKIGPENPYNTPVFAIKKKDSTKWRKLVDFREL NKRTQDFWEVQLGIPHPSGLKKNKSVTVLDVGDAYFSVPLDKDFRKYTAFTIPSTNNETP GIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVIYQYVDDLYVGSDLEIGQHRA KIEELRQHLWRWGFYTPDKKHQKEPPFLWMGYELHPDKWTVQPIVLPEKDSWTVNDIQKL |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |